Effect of non-sedation on physical function in survivors of critical illness - A substudy of the NONSEDA randomized trial

Critical illness impairs physical function. The NONSEDA trial was a multicenter randomized trial, assessing non-sedation versus sedation during mechanical ventilation. aim of this sub-study to assess the effect on All patients from one site were included. At ICU discharge and three months thereafter, survivors assessed for 205 included, 118 survived follow-up, 116 participated (98%). Primary outcome: Three after ICU-discharge, health-related quality life (SF-36, component score) similar (non-sedated 38.3 vs sedated 36.6, mean difference 1.7, 95% CI -1.7 5.1), as function in activities daily living (Barthel Index, non-sedated 19.5 18, median 1.5, -0.2 3.2). Secondary outcomes: Non-sedated had better Barthel Index at ICU-discharge (median 9 4, 5, 2.5 7.5). post-ICU discharge, two groups did not differ regarding handgrip strength, walking distance, muscle size or biomechanical data. Non-sedation lead improved everyday living. recovery discharge. Clinicaltrials.gov NCT02034942 , registered January 14., 2014. • significant improvements life. improve ADL-function 3 post generally